Painless acute pancreatitis associated with sorafenib treatment: a case report
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yasuyuki Kobayashi • Toshiyuki Kanemitu • Akihito Kamoto • Mototaka Satoh • Naoki Mori • Kenichiro Sekii • Toshiaki Yoshioka • Hiroaki Itatani • Takas
- چاپ و سال / کشور: 2010
Description
Sorafenib is a multikinase inhibitor that is used for the treatment of metastatic renal-cell carcinoma. We report the case of a patient with painless acute pancreatitis associated with sorafenib treatment. The patient was a 71- year-old man who had undergone surgery for left renal carcinoma and tumor thrombus in the inferior vena cava and right atrium (IVC-RA). After a follow-up period of 3 years, he developed right adrenal metastasis and received interferon (IFN)-alpha treatment. One year later, progression of the adrenal metastasis was observed, and he was admitted to a hospital for treatment with sorafenib, which was administered at a dose of 800 mg/day. Two weeks later, he developed painless acute pancreatitis associated with sorafenib treatment. Thereafter, sorafenib treatment was discontinued, and he was treated with conservative therapy. Three weeks later, he was discharged. Even though painless acute pancreatitis associated with sorafenib treatment is rare, the possible development of painless acute pancreatitis in patients undergoing sorafenib treatment must be kept in mind
Med Oncol (2011) 28:463–465 DOI 10.1007/s12032-010-9479-2 Received: 7 January 2010 / Accepted: 2 March 2010 / Published online: 19 March 2010
