Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dilek Yavuzer • Nimet Karadayi • Taflan Salepci • Huseyin Baloglu • Resat Dabak • Oya Uygur Bayramicli
- چاپ و سال / کشور: 2010
Description
Human papillomavirus (HPV) has been considered to be an etiological agent for anogenital cancers, such as cervical cancer and possibly a subset of cancers of the aerodigestive tract. The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. Formalin-fixed and paraffin-embedded archival tissue samples were used for DNA extraction. One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. In the control group with cervical lesions, 34 out of 49 (69.4%) samples were positive for the HPV DNA. These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas
Med Oncol (2011) 28:127–132 DOI 10.1007/s12032-010-9416-4 Received: 16 December 2009 / Accepted: 5 January 2010 / Published online: 16 January 2010
