Acquired hemophagocytic lymphohistiocytosis associated with multiple myeloma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maciej Machaczka • Johan Vaktna¨s • Monika Klimkowska • Hareth Nahi • Hans Ha¨gglund
- چاپ و سال / کشور: 2010
Description
Acquired or secondary hemophagocytic lymphohistiocytosis (sHLH) is a life-threatening hyperinflammation syndrome caused mostly by various infectious agents, autoimmune disorders or malignancy. So far, only anecdotal cases of sHLH associated with multiple myeloma have been published. We provide a review of all these reports and include a previously not published case of myeloma-associated sHLH in a 59-year-old male with complex partial epilepsy. Due to aggressive course of sHLH, increased awareness is indicated in all patients with malignancies which develop unremitting fever, cytopenia and splenomegaly. Early diagnosis and immediate introduction of adequate therapy is crucial for the outcome of HLH.
Med Oncol (2011) 28:539–543 DOI 10.1007/s12032-010-9484-5 Received: 2 March 2010 / Accepted: 8 March 2010 / Published online: 1 April 2010
