Minimally Invasive Procedures for Evacuation of Intracerebral Hemorrhage Reduces Perihematomal Glutamate Content, Blood– Brain Barrier Permeability and Brain Edema in Rabbits
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Guofeng Wu • Chang Li • Likun Wang • Yuanhong Mao • Zhen Hong
- چاپ و سال / کشور: 2011
Description
Background To observe the effects of the minimally invasive removal of an intracerebral hematoma on the glutamate concentration, blood–brain barrier (BBB) permeability and brain water content in the brain tissue surrounding the hematoma and to provide a theoretical basis for minimally invasive removal of intracerebral hematomas. Methods Thirty rabbits (2.8–3.4 kg body weight) were selected to establish a model of intracerebral hemorrhage, and they were randomly divided into a model control group and a minimally invasive group after the model was prepared successfully. The intracerebral hematoma was evacuated by stereotactic procedures in minimally invasive group 6 h after the model was established. The glutamate content, the permeability of the BBB and the brain water content in perihematomal brain tissues were determined and compared between the two groups. Results The glutamate content, the permeability of the BBB and the brain water content in the perihematomal brain tissues were significantly decreased compared to the model control group 1, 3, and 7 days after the minimally invasive removal of the intracerebral hematoma. Conclusions Minimally invasive surgery for removal of an intracerebral hematoma could significantly reduce the glutamate content, BBB permeability and the brain water content in perihematomal brain tissues.
Neurocrit Care (2011) 14:118–126 DOI 10.1007/s12028-010-9473-8 Published online: 14 December 2010
