Localization of D-serine and serine racemase in neurons and neuroglias in mouse brain
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Xiaohui Ding • Ning Ma • Masato Nagahama • Kumiko Yamada • Reiji Semba
- چاپ و سال / کشور: 2010
Description
D-Serine is a novel candidate for an intrinsic ligand for the glycine site of N-methyl-D-aspartate (NMDA) receptors in mammalian brain. D-Serine and serine racemase, which produces D-serine from L-serine, have long been presumed to be localized in astrocytes. However, we have reported that D-serine immunoreactivity was observed in neurons in rats. In the present study, the distributions of D-serine and serine racemase were investigated in combination with marker proteins for neurons, astrocytes and oligodendrocytes in mice. Immunoreactivities for D-serine and serine racemase were found in neurons and oligodendrocytes. These results suggest that D-serine can be produced in neurons as well as glias and used as a neurotransmitter, which control the synaptic function of NMDA receptors.
Neurol Sci (2011) 32:263–267 DOI 10.1007/s10072-010-0422-2 Received: 21 September 2009 / Accepted: 7 September 2010 / Published online: 2 October 2010
