The effect of natalizumab on cognitive function in patients with relapsing-remitting multiple sclerosis: preliminary results of a 1-year follow-up study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Flavia Mattioli • C. Stampatori • R. Capra
- چاپ و سال / کشور: 2010
Description
The objective of the study was to assess the natalizumab effect on the course of cognitive impairment in patients with relapsing-remitting multiple sclerosis (MS). Patients with active relapsing-remitting MS (n = 17) were treated with natalizumab for 1 year. The quasi control group included patients (n = 7) with clinically stable MS. Assessment of disease course [expanded disability status scale (EDSS); number of relapses] and neuropsychological impairment [Wisconsin card sorting test (WCST); controlled oral word associations; verbal/ non-verbal memory tests; paced auditory serial addition test] was conducted at baseline and after 1 year. Natalizumab- treated patients experienced significantly fewer relapses compared with the previous year (P\0.05). At 1-year follow-up, EDSS score was unchanged and neuropsychological assessments of memory/executive functions showed a significant improvement in natalizumab-treated patients (all P\0.05). No changes were observed in the quasi control group. This preliminary study suggests that natalizumab could be effective in ameliorating cognitive functions in patients with active relapsing-remitting MS, over 1-year follow-up.
Neurol Sci (2011) 32:83–88 DOI 10.1007/s10072-010-0412-4 Received: 15 December 2009 / Accepted: 1 September 2010 / Published online: 25 September 2010
