Seizure after intrathecal baclofen bolus in a multiple sclerosis patient treated with oxcarbazepine
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Giangaetano D’Aleo • Carmela Rifici • Markus Kofler • Edoardo Sessa • Leopold Saltuari • Placido Bramanti
- چاپ و سال / کشور: 2010
Description
Epileptic seizures associated with intrathecal baclofen (ITB) application have been observed in patients with traumatic brain injury. A higher incidence of seizures has also been reported in patients with multiple sclerosis (MS) receiving ITB. To our knowledge, no case of a first epileptic seizure has been reported in the context of ITB bolus testing in MS. We report a 41-year-old female patient with primary progressive MS receiving olanzapine and oxcarbazepine for psychotic disorder. Five years prior she began to develop severe spastic quadriparesis, rendering her a candidate for ITB treatment. After ITB test bolus application, however, she experienced a first epileptic seizure. Our observation indicates that ITB may trigger seizures in patients with MS. The observed seizure occurred during ITB bolus testing despite antiepileptic co-medication, which concurs with previous reports suggesting that rapid changes in the dose of ITB may carry a higher risk of seizure induction
Neurol Sci (2011) 32:293–295 DOI 10.1007/s10072-010-0364-8 Received: 16 July 2009 / Accepted: 22 June 2010 / Published online: 6 July 2010
