Progressive multifocal leukoencephalopathy following chemotherapy for lung cancer
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Antonio Palmieri • L. Valentinis • S. Bazzano • A. Baldi • F. Orlando • S. Tenaglia • S. D’Anna
- چاپ و سال / کشور: 2011
Description
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by the JC virus infection and with a frequent lethal outcome. PML usually occurs in immunocompromised subjects, such as HIV-positive individuals, as well as in other conditions characterized by depletion of cellular immunity, including hematological malignancies, autoimmune diseases, and immunomodulatory therapies. We describe the case of a 76-year-old man affected by advanced non-small cell lung cancer who developed PML after six cycles of carboplatin/gemcitabine therapy, during which a transitory leucopenia developed. The patient deceased a few months after the onset of the symptoms. Chemotherapy appears to be uncommon, but definite condition associated to PML.
Neurol Sci (2011) 32:683–685 DOI 10.1007/s10072-011-0494-7 Received: 22 March 2010 / Accepted: 3 February 2011 / Published online: 16 February 2011
