The ‘‘eye of the tiger’’ sign in pure akinesia with gait freezing
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Roberto Erro • Marianna Amboni • Carmine Vitale • Katia Longo • Mariangela Rocco • Carmela Russo • Sabina Pappata` • Arturo Brunetti • Paolo Barone
- چاپ و سال / کشور: 2011
Description
The ‘‘eye of the tiger’’ is a neuroradiologic sign due to iron deposition in the globus pallidus: it appears as diffuse low signal intensity with a central area of high signal intensity confined to the globus pallidus. The ‘‘eye of the tiger’’ sign has been associated with neurodegeneration with brain iron accumulation type 1 (NBIA1), a condition caused by mutations in the gene encoding pantothenate kinase 2 (PANK2). However, the specificity of this neuroradiologic sign has been already challenged and it has been described in other neurodegenerative diseases. Here, we report the first case of a patient suffering from pure akinesia with gait freezing with the ‘‘eye of the tiger’’ sign in T2-weighted MRI sequences. All clinical, laboratory and radiologic data excluded other diagnosis and genetic testing excluded PANK2 mutations suggesting that the ‘‘eye of the tiger’’ is not specific for NBIA1 and may also occur in other movement disorders
Neurol Sci (2011) 32:703–705 DOI 10.1007/s10072-011-0589-1 Received: 13 October 2010 / Accepted: 10 April 2011 / Published online: 5 May 2011
