Somatic and autonomic small fiber neuropathy induced by bortezomib therapy: an immunofluorescence study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Maria Pia Giannoccaro • Vincenzo Donadio • Carolina Gomis Pe`rez • Walter Borsini • Vitantonio Di Stasi • Rocco Liguori
- چاپ و سال / کشور: 2011
Description
Bortezomib is a new chemotherapeutic agent approved for the treatment of relapsed/refractory and newly diagnosed multiple myeloma. One of the major side effects of bortezomib is a peripheral length-dependent sensory axonal neuropathy and, less frequently, a small fiber neuropathy. Autonomic symptoms like postural dizziness, syncope, diarrhoea, ileus, impotence and urinary disturbances have been reported, nevertheless, autonomic neuropathy has never been characterized. We describe by means of immunofluorescence, the involvement of autonomic skin nerve fibers in three patients with small fiber neuropathy induced by bortezomib treatment.
Neurol Sci (2011) 32:361–363 DOI 10.1007/s10072-010-0475-2 Received: 17 February 2010 / Accepted: 29 December 2010 / Published online: 3 February 2011
