Association study between four polymorphisms in the HFE, TF and TFR genes and Parkinson’s disease in Southern Italy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Valentina Greco • Elvira Valeria De Marco • Francesca Emanuela Rocca • Ferdinanda Annesi • Donatella Civitelli • Giovanni Provenzano • Patrizia Taran
- چاپ و سال / کشور: 2011
Description
Iron overload may lead to neurodegenerative disorders such as Parkinson’s disease (PD) and alterations of iron-related genes might be involved in the pathogenesis of this disease. The gene of haemochromatosis (HFE) encodes the HFE protein which interacts with the transferrin receptor (TFR), lowering its affinity for iron-bound transferrin (TF). We examined four known polymorphisms, C282Y and H63D in the HFE gene, G258S in the TF gene and S82G in the TFR gene, in 181 sporadic PD patients and 180 controls from Southern Italy to investigate their possible role in susceptibility to PD. No significant differences were found in genotype and allele frequencies between PD and controls for all the polymorphisms studied, suggesting that these variants do not contribute significantly to the risk of PD.
Neurol Sci (2011) 32:525–527 DOI 10.1007/s10072-011-0504-9 Received: 25 January 2010 / Accepted: 16 February 2011 / Published online: 8 March 2011
