Oral administration of coenzyme Q10 reduces MPTP-induced loss of dopaminergic nerve terminals in the striatum in mice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shota Kobayashi • Akiko Muroyama • Hiroaki Matsushima • Ikuo Yoshimura • Yasuhide Mitsumoto
- چاپ و سال / کشور: 2011
Description
The neuroprotective effect of coenzyme Q10 (CoQ10) has been reported in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-treated mice. In this study, we investigated whether oral administration of CoQ10 could protect the striatal dopaminergic (DAergic) nerve terminals against MPTP-induced toxicity in C57BL/6N mice using immunoisolation technique for DAergic synaptosomes. CoQ10 significantly attenuated decrease in dopamine transporter as well as in synaptophysin and actin protein levels in DAergic synaptosomes from MPTP-treated mice. The effect of CoQ10 was also observed in crude synaptosomes fraction, but not in homogenate. Our results indicate that the nerve terminals are a site for the action of CoQ10 against the MPTP-induced DAergic neurodegeneration
Neurol Sci DOI 10.1007/s10072-011-0627-z Received: 28 May 2010 / Accepted: 11 May 2011
