Anti-Ma2/Ta antibodies in a woman with primary lateral sclerosis-like phenotype and Sjo¨gren syndrome
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Giovanni Piccolo • Eleonora Tavazzi • Sven Jarius • Enrico Alfonsi • Lorenzo Cavagna • Laura Piccolo • Elisabetta Zardini • Raymond Voltz • Diego Fran
- چاپ و سال / کشور: 2011
Description
Anti-Ma2/Ta antibodies are rare paraneoplastic antibodies, which are mostly associated with limbic encephalitis in male patients with testicular cancer. We report on a 50-year-old woman with a pure progressive spastic paraparesis. Next, she was diagnosed as having a Sjo¨gren syndrome, with serological positivity for anti-SSRo antibodies. The patient’s serum and cerebrospinal fluid samples were positive for anti-Ma2/Ta antibodies, which were also proved to be intrathecally produced. These findings, and the coexistence of systemic autoimmunity, led us to treat the patient with corticosteroids first, and then with plasma exchange. Neurological symptoms scarcely responded to both the therapies. The search for cancer was negative up to 4 years after the disease onset. Our case expands the spectrum of clinical syndromes associated with anti-Ma2/Ta antibodies.
Neurol Sci DOI 10.1007/s10072-011-0510-y Received: 28 July 2010 / Accepted: 18 February 2011
