Retrospective evaluation of the dose equivalence of Botox and Dysport in the management of blepharospasm and hemifacial spasm: a novel paradigm for a never ending story
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Anna Rita Bentivoglio • Ta`mara Ialongo • Francesco Bove • Francesca De Nigris • Alfonso Fasano
- چاپ و سال / کشور: 2011
Description
Botox and Dysport are the preparations of botulinum neurotoxin most widely used for therapeutic purposes. Several studies have addressed the topic of the equivalency ratio (D/B ratio) to be used in clinical practice and whether a reliable value exists is still a matter of debate. To this purpose, we ideated a novel paradigm by retrospectively examining the patients affected by hemifacial spasm and blepharospasm. We compared the pairs of treatments with a switch from one brand to the other undergone by the same patient in consecutive sessions with overlapping clinical outcome. Out of 2006 treatments, we found 51 treatment pairs. D/B ratio was extremely variable (range 1.2–13.3) and in most cases (65%) it was between 1:3 and 1:5. In conclusion, even if the 1:4 ratio might be reliable for clinical purpose, a true bioequivalence between Dysport and Botox might not exist due to the intrinsic difference in their pharmacokinetic properties
Neurol Sci DOI 10.1007/s10072-011-0672-7 Received: 23 April 2011 / Accepted: 15 June 2011
