Expression of Bcl-2 and Bax after hippocampal ischemia in DHA + EPA treated rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Marjan Ajami • Shariar Eghtesadi • Jalaledin Mirzay Razaz • Naser Kalantari • Rouhollah Habibey • Mohammad Ali Nilforoushzadeh • Mohammadreza Zarrind
- چاپ و سال / کشور: 2011
Description
To determine the impact of x3 fatty acids on post-ischemic expression of pro- and anti-apoptotic proteins in hippocampus, male rats were received 10 or 100 mg/kg [Docosahexaenoic acid (DHA) ? Ecosapentaenoic acid (EPA); gavage; 21 days before ischemia to 2–10 days after ischemia]. Global cerebral ischemia reperfusion (IR) was performed using the four-vessel occlusion model; ischemia 8 min and reperfusion 6, 48 h and 10 days. IR increased Bcl-2 and Bax expression after 48 h (p\0.05 and p\0.01 vs. sham) and 10 days (only Bax; p\0.05), without significant difference with DHA ? EPA groups after 6 h. But after 48 h expression of Bcl-2 increased (p\0.05 vs. IR) and Bax decreased (p\0.05). At day 10 after ischemia expression of Bax in DHA ? EPA acid groups was less than IR (p\0.05) and in 100 mg/kg DHA ? EPA group Bcl-2 expression was more than IR (p\0.05). These data suggested that longterm gavage with DHA ? EPA increase hippocampal neurons survival for days after ischemia, revealed by increased Bcl-2 and decreased Bax expressions.
Neurol Sci DOI 10.1007/s10072-011-0621-5 Received: 30 July 2010 / Accepted: 4 May 2011
