Measurements of diagnostic examination performance and correlation analysis using microvascular leakage, cerebral blood volume, and blood flow derived from 3T dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in glial tumor grading
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andrés Server & Bjّrn A. Graff & Tone E. Dّli Orheim & Till Schellhorn & Roger Josefsen & طystein B. Gadmar & Per H. Nakstad
- چاپ و سال / کشور: 2011
Description
Introduction To assess the diagnostic accuracy of microvascular leakage (MVL), cerebral blood volume (CBV) and blood flow (CBF) values derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging (DSC-MR imaging) for grading of cerebral glial tumors, and to estimate the correlation between vascular permeability/perfusion parameters and tumor grades. Methods A prospective study of 79 patients with cerebral glial tumors underwent DSC-MR imaging. Normalized relative CBV (rCBV) and relative CBF (rCBF) from tumoral (rCBVt and rCBFt), peri-enhancing region (rCBVe and rCBFe), and the value in the tumor divided by the value in the peri-enhancing region (rCBVt/e and rCBFt/e), as well as MVL, expressed as the leakage coefficient K2 were calculated. Hemodynamic variables and tumor grades were analyzed statistically and with Pearson correlations. Receiver operating characteristic (ROC) curve analyses were also performed for each of the variables. Results The differences in rCBVt and the maximum MVL (MVLmax) values were statistically significant among all tumor grades. Correlation analysis using Pearson was as follows: rCBVt and tumor grade, r=0.774; rCBFt and tumor grade, r=0.417; MVLmax and tumor grade, r=0.559; MVLmax and rCBVt, r=0.440; MVLmax and rCBFt, r= 0.192; and rCBVt and rCBFt, r=0.605. According to ROC analyses for distinguishing tumor grade, rCBVt showed the largest areas under ROC curve (AUC), except for grade III from IV. Conclusion Both rCBVt and MVLmax showed good discriminative power in distinguishing all tumor grades. rCBVt correlated strongly with tumor grade; the correlation between MVLmax and tumor grade was moderate.
Neuroradiology (2011) 53:435–447 DOI 10.1007/s00234-010-0770-x Received: 1 July 2010 / Accepted: 1 September 2010 / Published online: 21 September 2010
