Differentiation between benign and malignant orbital tumors at 3-T diffusion MR-imaging
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Ahmed Abdel Khalek Abdel Razek & Sahar Elkhamary & Amani Mousa
- چاپ و سال / کشور: 2011
Description
Introduction To differentiate between malignant and benign orbital tumors at 3-T diffusion MR imaging. Methods A retrospective study was conducted on 47 patients (34 males and 13 females aged 4–74 years) with orbital masses. They underwent echo-planar diffusionweighted MR imaging of the orbit with b-factor of 0, 500, and 1,000 s/mm2 at 3-T MR unit. Apparent diffusion coefficient (ADC) maps were reconstructed, and the ADC value of the orbital mass was calculated. Results The mean ADC value of the malignant orbital tumors (0.84±0.34×10-3 mm2/s) was significantly lower (P=0.001) than that of the benign orbital tumors (1.57±0.33× 10-3 mm2/s). The selection of an ADC value of 1.15× 10-3 mm2/s as a threshold value for differentiating malignant orbital tumors from benign lesions has a sensitivity of 95%, a specificity of 91%, and an accuracy of 93%. There was a significant difference in the ADC value between well- and poorly differentiated malignancies (P=0.005). Conclusion Apparent diffusion coefficient value at 3 T is an additional noninvasive imaging parameter that can be used for the differentiation of malignant orbital tumors from benign lesions, the characterization of some orbital tumors, as well as the grading of orbital malignancy
Neuroradiology (2011) 53:517–522 DOI 10.1007/s00234-011-0838-2 Received: 25 July 2010 / Accepted: 20 January 2011 / Published online: 1 February 2011
