Diffusion-weighted imaging findings in brain death
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hakan Selcuk & Sait Albayram & Ercan Tureci & Zehra Isik Hasiloglu & Osman Kizilkilic & Emin Cagil & Naci Kocer & Civan Islak
- چاپ و سال / کشور: 2011
Description
Introduction The purpose of the present study was to determine the role of diffusion-weighted imaging (DWI) and to investigate the use of DWI in the diagnosis of brain death (BD). Methods We prospectively evaluated 22 patients diagnosed with clinical BD (9 women, 13 men; mean age, 39.63± 15.1 years; age range, 9–66 years). All clinical criteria for BD were present in all 22 patients before magnetic resonance imaging, including a positive apnea test. For all cases, DW images, T2-weighted images, and fluidattenuated inversion recovery were obtained. Thirteen distinct neuroanatomical structures were selected for analysis in all the cases. For each region of interest, the mean, standard deviation, and range of the average apparent diffusion coefficient (ADCav) values were obtained. Results For BD patients, ADC values in all neuroanatomical structures were significantly lower than those for control subjects. We determined how ADC values in all structures were related to the diagnostic condition as well as the appropriate threshold ADC values to classify a subject as BD or control. The sensitivity, specificity, positive and negative predictive values, and correct classification rate of ADC cutoff values to distinguish BD from control groups were 100%. Conclusions DWI might be used as a noninvasive confirmatory test for the diagnosis of BD in the future.
Neuroradiology DOI 10.1007/s00234-011-0912-9 Received: 31 March 2011 / Accepted: 6 July 2011
