Relation Between Fluorodeoxyglucose Uptake and Glucose Transporter-1 Expression in Gastric Signet Ring Cell Carcinoma
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Bong-Hoi Choi & Hee-Sung Song & Young-Sil An & Sang-Uk Han & Jang-Hee Kim & Joon-Kee Yoon
- چاپ و سال / کشور: 2010
Description
Purpose Gastric signet ring cell carcinoma (GSRC) is known to have low fluorodeoxyglucose (FDG) uptake. The aim of the study was to investigate the relation between FDG uptake and glucose transporter (GLUT)-1 expression and clinicopathologic parameters in cases of GSRC. Materials and Methods Forty patients (28 men, mean age 54±12 years) with histologically confirmed GSRC who underwent pre-operative [18F]FDG PET/CT were enrolled. Maximum standardized uptake values (SUVmax) were compared with clinicopathologic parameters and GLUT-1 expression. Cases were divided based on GLUT-1 expression in tumor tissues into a membranous group (n=17) and a cytoplasmic group (n=23). Results Mean SUVmax was significantly higher in the membranous group than in the cytoplasmic group (6.06± 2.79 vs. 3.67±1.54, P=0.03). Gastric wall invasion, depth of invasion, extent of LN metastasis, overall stage, and tumor size were found to be related to SUVmax. On the other hand, age, sex, and the presence of distant metastasis were not related to SUVmax. Multivariate analysis revealed that membranous GLUT-1 expression and the extent of LN metastasis independently predicted high FDG uptake. Conclusions This study demonstrates that high FDG uptake is mediated by membranous GLUT-1 expression in GSRC.
Nucl Med Mol Imaging (2011) 45:30–35 DOI 10.1007/s13139-010-0058-4 Received: 7 June 2010 / Accepted: 13 October 2010 / Published online: 4 November 2010
