Clinical Significance of Diffuse 18F-FDG Uptake in Residual Thyroid Gland after Unilateral Thyroid Lobectomy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Hee-Sung Song & Su Jin Lee & Seok-Ho Yoon & Jandee Lee & Euy-Young Soh & Young-Sil An & Joon-Kee Yoon
- چاپ و سال / کشور: 2011
Description
Purpose We investigated the clinical significance of diffuse uptake in remaining thyroid after unilateral lobectomy for thyroid cancer. Methods A total of 144 thyroid cancer patients who underwent 18F-FDG PET/CT after lobectomy were enrolled in the present study. The PET/CT images were evaluated for the presence of diffuse 18F-FDG uptake with maximum SUV (SUVmax) >2.0 in the residual thyroid and placed into one of two groups: with diffuse uptake and without diffuse uptake group. Clinical, laboratory, and PET/CT parameters in both groups were compared. Correlations between SUVmax of thyroid and available parameters were analyzed. Results Forty-two of 144 patients (29.2%) had diffuse thyroid uptake (mean SUVmax: 3.2±1.1). All patients with diffuse uptake and 96 (94.1%) without diffuse uptake were receiving thyroxine therapy (P=0.09). Thyroid function tests showed that most patients were euthyroid status (78.6 vs. 85.3%, P=0.36). TgAb levels were significantly higher in patients with diffuse uptake (338.0±664.6 vs. 57.3±46.4, P<0.0001). Mean attenuation values in the diffuse uptake group were significantly lower (72.2±15. vs. 97.0±16.0, P<0.0001). An inverse correlation was found between SUVmax and mean attenuation values of residual thyroid in all patients (r=-0.57, P<0.0001) and subgroup with diffuse uptake (r=-0.31, P<0.05). Conclusion In this study, diffuse 18F-FDG uptake in the residual thyroid after unilateral lobectomy was a relatively frequent finding and may be associated with chronic thyroiditis. This uptake is not influenced by thyroid status or thyroxine therapy. The 18F-FDG uptake is inversely correlated with mean attenuation value of thyroid.
Nucl Med Mol Imaging DOI 10.1007/s13139-011-0097-5 Received: 22 April 2011 / Accepted: 30 June 2011
