Alexandra Fontes · Marcia Sampaio Campos Suzana C.O.M. de Sousa · Marília Trierveiler Martins Fabio Daumas Nunes
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Diagnostic implications of oral intravascular papillary endothelial hyperplasia
- چاپ و سال / کشور: 2010
Description
This study examined the clinical, histological, and immunohistochemical features as well as the differential diagnoses of oral intravascular papillary endothelial hyperplasia (IPEH) to aid clinicians and pathologists in its diagnosis. Clinical features of fi ve oral IPEH cases were obtained from medical records, and all histopathological diagnoses were reviewed. Immunohistochemical reactions, including anti-CD-34, laminin, vimentin, estrogen receptor alpha, and Ki-67, were assessed. Microscopically, a reactive proliferation of vascular cells composed of small papillary structures with hypocellular and hyalinized cores arising in an organized thrombus was seen. CD-34, vimentin, and laminin staining were strongly positive, while estrogen receptor alpha was negative in all cases. A low percentage of cells were positive for Ki-67 in four of fi ve lesions, but one case was strongly positive. A diagnosis of angiosarcoma was investigated and rejected. IPEH presents specifi c microscopic characteristics that along with clinical data lead to an accurate diagnosis. The general dentist, the fi rst to participate in the diagnostic process, must share the responsibility for diagnosis with the pathologist, and they must work together to determine the correct diagnosis and management. Oral lesions of IPEH are uncommon. Their main signifi cance is that they show a microscopic resemblance to angiosarcoma. Thus, clinicians should have more information regarding this benign entity. Finally, we suggest that in recurrent cases exhibiting strong immunolabeling of proliferative markers the possibility of angiosarcoma should be investigated.
Odontology (2011) 99:92–97 DOI 10.1007/s10266-010-0150-3 Received: August 20, 2009 / Accepted: July 4, 2010
