Molecular pharmacokinetic determinants of anticancer kinase inhibitors in humans
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Julie Scholler • Dominique Leveˆque
- چاپ و سال / کشور: 2011
Description
This review presents the published data regarding the molecular determinants (drug metabolizing enzymes, drug transporters and orphan nuclear receptors) of approved anticancer kinase inhibitors pharmacokinetics in humans. The clinical impact of these determinants (drug disposition and drug–drug interactions) is also discussed.
Oncol Rev (2011) 5:77–92 DOI 10.1007/s12156-011-0072-5 Received: 18 June 2010 / Accepted: 20 January 2011 / Published online: 22 February 2011
