A limited review of over diagnosis methods and long-term effects in breast cancer screening
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Dongfeng Wu • Adriana Pe´rez
- چاپ و سال / کشور: 2011
Description
Breast cancer screening programs have been effective in detecting tumors prior to symptoms. Recently, there has been concern over the issue of over-diagnosis, that is, diagnosis of a breast cancer that does not manifest prior to death. Estimates for over-diagnosis vary, ranging from 7 to 52%. This variability may be due partially to issues associated with bias and/or incorrect inferences associated with the lack of probability modeling. A critical issue is how to evaluate the long-term effects due to continued screening. Participants in a periodic screening program can be classified into four mutually exclusive groups depending on whether individuals are diagnosed and whether their symptoms appear prior to death: True-earlydetection; No-early-detection; Over-diagnosis; and Not-sonecessary. All initially superficially healthy people will eventually fall into one of these four categories. This manuscript reviews the major methodologies associated with the over-diagnosis and long-term effects of breast cancer screening.
Oncol Rev DOI 10.1007/s12156-011-0077-0 Received: 28 February 2011 / Accepted: 21 April 2011
