Isotretinoin effect on alveolar repair after exodontia—a study in rats
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Roberta Dalmolin Bergoli & Otacilio Luiz Chagas Junior & Carlos Eduardo Chrzanowski Pereira de Souza & Beatriz Farias Vogt & Henrique Telles Ramos d
- چاپ و سال / کشور: 2010
Description
Objectives To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats. Study design Wistar rats (60-day-old) were assigned to control (CG, n=12) and experimental (EG, n=20) groups. EG received daily isotretinoin (7.5 mg/kg) for 30 days before surgery and until euthanasia, 7, 21, 28, or 90 days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy. Results There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90. Conclusions Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair.
Oral Maxillofac Surg (2011) 15:85–92 DOI 10.1007/s10006-010-0235-8 Received: 28 May 2010 / Accepted: 1 June 2010 / Published online: 25 July 2010
