Recombinant human bone morphogenetic protein-2 (rhBMP-2) in the treatment of mandibular sequelae after tumor resection
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : André Zétola & Felipe Mussi Ferreira & Rafaela Larson & Jamil Awad Shibli
- چاپ و سال / کشور: 2010
Description
Background Ameloblastoma is a locally aggressive tumor most often found in posterior body and angle of the mandible. Although ameloblastoma has histological characteristics of benignity, they have a high percentage of local recurrence and possible malignant development if treated improperly. Case report This report presents a treatment of unusual mandibular sequelae after tumor resection using recombinant human bone morphogenetic protein-2 (rhBMP-2) associated with hydroxyapatite (HA) and calcium triphosphate (TCP). Discussion Seven months after surgery, the patient was asymptomatic, with stable occlusion and class I, without signs of infection or rejection, and bone repair with rigidity compatible to an immature bone structure was observed. Reconstruction of large mandibular bone defect with a combination of rhBMP-2 and HA/TCP achieving a satisfactory result with less invasive and minimum morbidity has been demonstrated.
Oral Maxillofac Surg DOI 10.1007/s10006-010-0236-7 Received: 27 May 2010 / Accepted: 1 June 2010
