Zoledronic acid-induced transient hepatotoxicity in a patient effectively treated for Paget’s disease of bone
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : S. A. Polyzos & J. Kountouras & A. D. Anastasilakis & I. Litsas & M. Kita & G. Arsos & E. Moralidis & E. Terpos
- چاپ و سال / کشور: 2010
Description
Bisphosphonate (BP)-induced hepatotoxicity is very rare. There are only a few reports of liver injury after BP treatment, including aledronate and risedronate in postmenopausal osteoporosis patients. We describe hereby the case of a patient with Paget’s disease of bone accompanied by nonalcoholic fatty liver disease (NAFLD) who developed transient hepatotoxicity after zoledronic acid (ZOL) treatment. NAFLD had been diagnosed 1 year before presentation, based on liver ultrasonography (US). One day after infusion, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gammaglutamyltransferase (GGT) were increased by 8.1, 6.7, and 6.7 times, respectively, compared with pretreatment values. Serum bilirubin remained normal. US revealed hepatic mild homogenous brightness without focal lesion of the liver or biliary ducts. Subsequent biochemical and serologic investigation did not reveal a specific liver or systematic disease. The patient remained asymptomatic, and ALT, AST, and GGT were normalized 7 days posttreatment. Although the mechanism by which ZOL may cause liver damage is elusive, physicians should be aware of this possible adverse effect and ZOL cautiously administered in NAFLD patients.
Osteoporos Int (2011) 22:363–367 DOI 10.1007/s00198-010-1230-5 Received: 12 February 2010 / Accepted: 9 March 2010 / Published online: 21 April 2010
