Metacarpal thickness, width, length and medullary diameter in children—reference curves from the First Zürich Longitudinal Study
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : D. D. Martin & C. Heckmann & O. G. Jenni & M. B. Ranke & G. Binder & H. H. Thodberg
- چاپ و سال / کشور: 2010
Description
Summary Metacarpal thickness (T), width (W), length (L) and medullary diameter (M) were measured in 3,121 X-rays from 231 healthy Caucasian children aged 3 to 19 years and analysed for bone age, age, height, weight and genderrelated characteristics, showing highly differentiated growth patterns with prepubertal dips. Reference data for the four metacarpal measures are presented. Introduction The aim of the study was to create and explore a reference database for metacarpal T, W, L and M in children. Methods Three thousand one hundred twenty-one left-hand X-rays (1,661 from boys) from 231 healthy Caucasian subjects (119 boys) aged 3 to 19 years were analysed by BoneXpert, a programme for automatic analysis of hand Xrays and bone age (BA; in years). Results In boys, growth of T, W and L shows a prepubertal decrease from BA 7 to 13 and then accelerates again. In girls, the same is seen only for T starting from BA 8 to 11, whereas W and L grow at a declining rate. M shows steady growth until BA 10.5 in girls and BA 13.5 in boys and then grows smaller in both. W is greater in boys from BA 6 onwards, while L is greater in girls from BA 9 to 13 and T from BA 11 to 14. BA is reflected best by L until start of puberty and by T and L thereafter. Conclusion T, W, L and M show highly differentiated growth patterns. These reference data provide a basis for further research into skeletal development and the management of hormone therapies in children.
Osteoporos Int (2011) 22:1525–1536 DOI 10.1007/s00198-010-1389-9 Received: 7 November 2009 / Accepted: 10 August 2010 / Published online: 15 October 2010
