UGT2B17 gene deletion associated with an increase in bone mineral density similar to the effect of hormone replacement in postmenopausal women
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : S. Giroux & J. Bussières & A. Bureau & F. Rousseau
- چاپ و سال / کشور: 2011
Description
Summary UGT2B17 is one of the most important enzymes for androgen metabolism. In addition, the UGT2B17 gene is one of the most commonly deleted regions of the human genome. The deletion was previously found associated with higher femoral bone density in men and women, and we replicated this association in a sample of postmenopausal who never used hormone therapy. Introduction Deletion of the UGT2B17 gene was previously shown to be associated with a higher hip bone mineral density (BMD). Using a PCR assay, we tried to replicate the association among a large group of 2,379 women. We examined the effect of the deletion on femoral neck BMD and lumbar spine BMD according to the menopausal status and hormone replacement therapy (HRT). Methods We used a high-throughput PCR assay to identify the gene and the deletion in a population of wellcharacterized women. Two additional polymorphisms, UGT2B28 deletion and UGT2B15 rs1902023 G>T were also investigated. Results Only UGT2B17 deletion was associated with LS and FN BMD. Furthermore, the association was seen only among postmenopausal women who had never used hormone replacement as in the first reported association. Conclusions We confirmed the association between UGT2B17 deletion and a higher LS and FN BMD. In addition, we show that the association is observed among postmenopausal women who never used HRT consistent with the enzymatic function of UGT2B17. The analysis shows that those having one or two UGT2B17 alleles benefit from HRT, which is not the case for null carriers.
Osteoporos Int DOI 10.1007/s00198-011-1662-6 Received: 9 December 2010 / Accepted: 29 March 2011
