Clinical and Molecular Insights into Tuberous Sclerosis Complex Renal Disease
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Brian J. Siroky & Hong Yin & John J. Bissler
- چاپ و سال / کشور: 2011
Description
Patients with tuberous sclerosis complex are at great risk of developing renal lesions as part of their disease. These lesions include renal cysts and tumors. Significant advances in understanding the cell biology of these renal lesions has already led to clinical trials demonstrating that pharmacological interventions are likely possible. This review focuses on the pathology of these renal lesions, their underlying cell biology, and the possible therapeutic strategies that may prove to significantly improve care for these patients.
Pediatr Nephrol (2011) 26:839–852 DOI 10.1007/s00467-010-1689-5 Received: 19 April 2010 / Revised: 15 September 2010 / Accepted: 21 September 2010 / Published online: 9 December 2010
