Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Lindsay Keir & Richard J. M. Coward
- چاپ و سال / کشور: 2011
Description
Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).
Pediatr Nephrol (2011) 26:523–533 DOI 10.1007/s00467-010-1637-4 Received: 30 March 2010 / Revised: 21 June 2010 / Accepted: 8 July 2010 / Published online: 15 October 2010
