Elevated systolic blood pressure in preterm very-low-birth-weight infants .3 years of life
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Andrea F. Duncan & Roy J. Heyne & Janet S. Morgan & Naveed Ahmad & Charles R. Rosenfeld
- چاپ و سال / کشور: 2011
Description
Preterm, very-low-birth-weight neonates (.1500 gm, VLBW) exhibit elevated systolic blood pressures (SBP) in adolescence and adulthood; however, the age of onset and causes are unknown. We assessed SBP in a cross-sectional study of VLBWinfants at 1, 2 and 3 years of age (n = 40 per cohort). SBP was manually measured using Doppler amplification (observed), and calm values were compared to reference ranges used for clinical purposes (expected). SBP was converted to age-, gender- and height-specific z-scores (SBPz). Perinatal variables and growth parameters measured between 6 and 36 months were assessed as predictors of an elevated SBP. Observed SBP and SBPz exceeded the expected value at each age (P<0.01); for example 1 year SBP was 94پ}10 (standard deviation) vs. 85پ}3 mmHg, respectively. Although the expected SBP rose from 85پ}3 to 90پ}3 mmHg with advancing age (P<0.05), VLBW SBP was unchanged (P>0.1), averaging 93 mmHg across ages. Height and weight z-scores were below expected (P<0.01), while weight-for-height z-scores exceeded zero at 6, 12 and 24 months (P<0.05). Male subscapular skinfold thickness:abdominal circumference ratio decreased with advancing age, paralleling the decreases in SBPz. The VLBW neonates demonstrated an elevated SBP as early as 1 year of age. Although predictive perinatal variables were not identified, gender-specific relationships between infant growth and SBP were observed.
Pediatr Nephrol (2011) 26:1115–1121 DOI 10.1007/s00467-011-1833-x Received: 27 July 2010 / Revised: 7 February 2011 / Accepted: 17 February 2011 / Published online: 13 March 2011
