Renal function in pediatric cystic fibrosis patients in the first decade of life
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Chanel Prestidge & Mark A. Chilvers & A. George F. Davidson & Eva Cho & Vanessa McMahon & Colin T. White
- چاپ و سال / کشور: 2011
Description
With increasing life expectancy and the need for lung transplantation in the cystic fibrosis (CF) population, there are increasing reports of chronic kidney disease (CKD). However, values for baseline or longitudinal glomerular filtration rate (GFR) as measured by exogenous clearance markers are lacking in this population. Retrospective cross-sectional study in 2 to 18-year-olds cared for at a single CF center who had a GFR measured by plasma disappearance of Technetium-99 m diethylenetriaminepentaacetic acid (mGFR). The primary outcome was evidence of renal dysfunction as defined by CKD stage II or below (mGFR<90 ml/min/1.73 m2, persistent abnormalities in urinary sediment, abnormal renal imaging). Of 63 patients evaluated, four had apparent renal dysfunction, one demonstrated decreased mGFR, and three others had persistent microscopic hematuria. The mean mGFR was substantially higher (140±24 ml/min/1.73 m2) than expected or previously reported for healthy children. We did not demonstrate the presence of significant renal impairment after limited aminoglycoside exposure in the first decade following diagnosis with CF. However, we did document the presence of glomerular hyperfiltration in a significant proportion of our CF patients.
Pediatr Nephrol (2011) 26:605–612 DOI 10.1007/s00467-010-1737-1 Received: 9 September 2010 / Revised: 6 November 2010 / Accepted: 22 November 2010 / Published online: 29 December 2010
