Collapsing glomerulopathy in a girl with systemic lupus erythematosus
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : M. Fahim Tungekar & Simon Waller & Joanna C. Clothier
- چاپ و سال / کشور: 2011
Description
Collapsing glomerulopathy has increasingly been recognised in patients with conditions other than HIV. The non-HIV form of collapsing glomerulopathy generally shows little response to standard therapies. We describe a 12-year-old girl with a pre-existing diagnosis of systemic lupus erythematosus presenting with renal failure. A renal biopsy gave the histological diagnosis of collapsing glomerulopathy with evidence of “full-house” immunostaining. We propose collapsing glomerulopathy in her case, as no other cause was found was secondary to systemic lupus erythematosus. The immunophenotype of her podocytes suggested a partial de-differentiation that might have been important in her partial response to immunosuppression.
Pediatr Nephrol (2011) 26:809–813 DOI 10.1007/s00467-010-1756-y Received: 19 October 2010 / Revised: 17 December 2010 / Accepted: 23 December 2010 / Published online: 29 January 2011
