The role of serum myeloid-related protein 8/14 complex in Henoch–Schِnlein purpura nephritis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yukihiko Kawasaki & Shinichirou Ohara & Yusaku Abe & Masahiro Watanabe & Kazuhide Suyama & Masatoki Sato & Koichi Hashimoto & Mitsuaki Hosoya
- چاپ و سال / کشور: 2011
Description
Myeloid-related protein (MRP) 8/14 complex is a marker of monocyte and neutrophil activation. We evaluated whether serum MRP8/14 complex is associated with clinical manifestations and pathological findings of Henoch– Schِnlein purpura nephritis (HSPN). Patients were divided into two groups based on serum MRP8/14 complex levels at renal biopsy. Group 1 consisted of 18 HSPN patients with less than median (670 ng/ml) MRP8/14 complex levels, and Group 2 of 12 HSPN patients with greater than median levels. Clinical manifestations, laboratory findings and serum E-selectin levels, as a marker of vascular endothelial cell dysfunction, as well as histological and immunohistochemical findings were investigated for both groups.We also measured MRP8/14 complex levels in disease control and healthy control children. Urinary protein excretions, serum MRP8/14 complex levels, and serum E-selectin levels were all higher in Group 2 than in Group 1 patients. Serum MRP8/14 complex levels were higher in HSPN patients than in controls. Serum MRP8/14 complex levels were strongly associated with serum E-selectin levels. Pathological findings revealed that the proportions of patients with ISKDC grades III, IVand Vin Group 2 were higher than in Group 1. Our findings suggest that serum MRP8/14 complex levels might be associated with the severity of renal injury and endothelial cell dysfunction in HSPN patients.
Pediatr Nephrol DOI 10.1007/s00467-011-1937-3 Received: 24 March 2011 / Revised: 26 May 2011 / Accepted: 31 May 2011
