Urinary ß2-microglobulin in very preterm neonates with chorioamnionitis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Shigeru Nishimaki & Yoshio Shima & Miho Sato & Hiromi An & Shujiro Fujita & Shiho Iwasaki & Haruko Horiguchi & Kazuo Seki & Shumpei Yokota
- چاپ و سال / کشور: 2011
Description
It is important to identify premature infants with prenatal inflammation as it contributes to short- and longterm complications. Our object was to study how prenatal inflammation affects the urinary β2-microglobulin (β2-MG) level. Preterm neonates were divided based on the presence of chorioamnionitis (CAM) into the CAM (n=100) and non-CAM groups (n=117). These were further subdivided into five groups each: 30 preterm neonates of 23–26; 42 neonates of 27–28; 54 neonates of 29–30; 51 neonates of 31–32; and 40 neonates of 33–34 weeks’ gestation. The urinary β2-MG level within 48 h of birth was significantly higher in the CAM group than in the non-CAM group among the neonates of 23–26 weeks’ gestation (18.3±6.9 vs 10.0±5.6×104 μg/gCr, p=0.0018) and the neonates of 27–28 weeks’ gestation (16.2±10.8 vs 8.8±3.3×104 μg/gCr, p=0.0101). However, there was no difference in urinary β2- MG level between the CAM and the non-CAM group among the neonates≥29 weeks ’gestation. Moreover, the elevated urinary β2-MG level in the neonates≤28 weeks ’ gestation with CAM had disappeared by 1 week after birth. The reasons for the increase in urinary β2-MG level within 48 h of birth in very preterm neonates (≤ 28 weeks’ gestation) with CAM are believed to be not only prematurity, but also prenatal inflammation. It is suggested that the urinary β2-MG level during the early postnatal period can identify prenatal inflammation.
Pediatr Nephrol DOI 10.1007/s00467-011-1924-8 Received: 20 February 2011 / Revised: 13 April 2011 / Accepted: 4 May 2011
