Body fat composition and occurrence of kidney stones in hypercalciuric children
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Rose Ayoob &Wei Wang & Andrew Schwaderer
- چاپ و سال / کشور: 2011
Description
In the last 10 years, the incidence of kidney stones has increased in the pediatric population, and this rise has been paralleled by a significant increase in pediatric obesity rates in the USA. The purpose of this study was to evaluate percentage body fat (%BF) measured by dual energy X-ray absorptiometry (DXA) in hypercalciuric children with and without kidney stones. A retrospective chart review was performed on children with idiopathic hypercalciuria based on a 24-h urine calcium excretion of >4 mg/kg/day or >200 mg/day who had undergone DXA scanning. Patients were then classified by sex and by %BF (3 categories; normal: <27% girls, <21% boys; at risk for obesity: 27–36% girls, 21–30% boys; obese: >36% girls, >30% boys). The 2003–2004 NHANES data were used as a control. Fifty patients (24 males) were analyzed, of whom 26% were assessed as having a normal %BF, 44% as being at risk for obesity, and 30% as being obese. Children with an increased %BF had a significantly higher occurrence of kidney stones (p=0.03) than those with a normal %BF. No significant differences were noted in 24-h urine chemistries between the groups. In conclusion, an increased %BF was associated with an increased occurrence of kidney stones in children with idiopathic hypercalciuria.
Pediatr Nephrol DOI 10.1007/s00467-011-1927-5 Received: 26 March 2011 / Revised: 12 May 2011 / Accepted: 17 May 2011
