Monitoring and managing viral infections in pediatric renal transplant recipients
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Patrizia Comoli & Fabrizio Ginevri
- چاپ و سال / کشور: 2011
Description
Viral infections remain a significant cause of morbidity and mortality following renal transplantation. The pediatric cohort is at high risk of developing virus-related complications due to immunological naiveté and the increased alloreactivity risk that requires maintaining a heavily immunosuppressive environment. Although cytomegalovirus is the most common opportunistic pathogen seen in transplant recipients, numerous other viruses may affect clinical outcome. Recent technological advances and novel antiviral therapy have allowed implementation of viral and immunological monitoring protocols and adoption of prophylactic or preemptive treatment approaches in high-risk groups. These strategies have led to improved viral infection management in the immunocompromised host, with significant impact on outcome.We review the major viral infections seen following kidney transplantation and discuss strategies for preventing and managing these pathogens.
Pediatr Nephrol DOI 10.1007/s00467-011-1812-2 Received: 7 October 2010 / Revised: 1 February 2011 / Accepted: 4 February 2011
