Integrins in renal development
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Sijo Mathew & Xiwu Chen & Ambra Pozzi & Roy Zent
- چاپ و سال / کشور: 2011
Description
The kidney develops from direct interactions between the ureteric bud and the metanephric mesenchyme. The ureteric bud gives rise to the collecting system and the metanephric mesenchyme to the nephrons. The complex process of renal development which occurs between these embryologically distinct structures is mediated by numerous factors, including the communication of cells with their surrounding extracellular matrix. Integrins are the principal cellular receptors for extracellular matrix proteins, and they play a role in organ and tissue development. In this review we focus on how integrins regulate renal development.
Pediatr Nephrol DOI 10.1007/s00467-011-1890-1 Received: 15 February 2011 / Revised: 30 March 2011 / Accepted: 31 March 2011
