Distinct metalloproteinase excretion patterns in focal segmental glomerulosclerosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Kimberly A. Czech & Michael Bennett & Prasad Devarajan
- چاپ و سال / کشور: 2011
Description
Metalloproteinase-2 (MMP-2) and metalloproteinase- 9 (MMP-9) degrade type IV collagen, and represent important tissue remodeling enzymes in several kidney disorders. In this study, we measured urinary levels of MMP-2, MMP-9, and the tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in patients with steroid-sensitive nephrotic syndrome (SSNS, n=18, median age 5) and focal segmental glomerulosclerosis (FSGS, n=16, median age 15). We found that urinary concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2 were significantly elevated in FSGS patients as compared to SSNS in both relapse and remission (p<0.002). Furthermore, urinary levels of these enzymes are increased early on in the FSGS disease process (chronic kidney disease stages 1 and 2). The findings from this pilot study suggest that MMPs and TIMPs have the potential to represent candidate, early non-invasive biomarkers for diagnosis and/or response to therapy. In addition, they may represent therapeutic targets for preventing chronic kidney disease progression in FSGS.
Pediatr Nephrol DOI 10.1007/s00467-011-1897-7 Received: 18 January 2011 / Revised: 17 March 2011 / Accepted: 30 March 2011
