The PDGF family in renal fibrosis
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Tammo Ostendorf & Frank Eitner & Jürgen Floege
- چاپ و سال / کشور: 2011
Description
The platelet-derived growth factor (PDGF) family plays an important role in embryonic development, malignancy, wound healing, atherosclerosis, and fibrosis in multiple organs. It belongs to the best-characterized growth factor systems in normal and diseased kidneys, and there is accumulating evidence that members of the PDGF family are key players in the development of renal fibrosis independent of the underlying kidney disease. All components of the PDGF system, consisting of four isoforms (PDGF-A, -B, -C, -D) and two receptor chains (PDGFR-ل and –â), are constitutively or inducibly expressed in most renal cells. They regulate multiple pathophysiologic events, ranging from cell proliferation and migration, extracellular matrix accumulation and production of pro- and anti-inflammatory mediators, to tissue permeability and hemodynamics. This review focuses on advances in defining the roles of different PDGF isoforms in the development of glomerulosclerosis and tubulointerstitial fibrosis. The recent identification of endogenous PDGF inhibitors offers additional novel therapeutic strategies.
Pediatr Nephrol DOI 10.1007/s00467-011-1892-z Received: 1 February 2011 / Revised: 5 April 2011 / Accepted: 6 April 2011
