Optimized T1- and T2-weighted volumetric brain imaging as a diagnostic tool in very preterm neonates
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Revital Nossin-Manor & Andrew D. Chung & Drew Morris & João P. Soares-Fernandes & Bejoy Thomas & Hai-Ling M. Cheng & Hilary E. A. Whyte & Margot J. T
- چاپ و سال / کشور: 2010
Description
Background T1- and T2-W MR sequences used for obtaining diagnostic information and morphometric measurements in the neonatal brain are frequently acquired using different imaging protocols. Optimizing one protocol for obtaining both kinds of information is valuable. Objective To determine whether high-resolution T1- and T2-W volumetric sequences optimized for preterm brain imaging could provide both diagnostic and morphometric value. Materials and methods Thirty preterm neonates born between 24 and 32 weeks’ gestational age were scanned during the first 2 weeks after birth. T1- and T2-W highresolution sequences were optimized in terms of signal-tonoise ratio, contrast-to-noise ratio and scan time and compared to conventional spin-echo-based sequences. Results No differences were found between conventional and high-resolution T1-W sequences for diagnostic confidence, image quality and motion artifacts. A preference for conventional over high-resolution T2-W sequences for image quality was observed. High-resolution T1 images provided better delineation of thalamic myelination and the superior temporal sulcus. No differences were found for detection of myelination and sulcation using conventional and high-resolution T2-W images. Conclusion High-resolution T1- and T2-W volumetric sequences can be used in clinical MRI in the very preterm brain to provide both diagnostic and morphometric information.
Pediatr Radiol (2011) 41:702–710 DOI 10.1007/s00247-010-1955-5 Received: 30 July 2010 / Revised: 1 November 2010 / Accepted: 12 November 2010 / Published online: 16 December 2010
