Intercellular adhesion molecule-1 plays a critical role in glomerulosclerosis after subtotal nephrectomy
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Yuichi Kido Daisuke Ogawa Kenichi Shikata Motofumi Sasaki Ryo Nagase Shinichi Okada Hitomi Usui Kataoka Jun Wada Hirofumi Makino
- چاپ و سال / کشور: 2011
Description
Background Hyperfiltration in the glomeruli have been considered to be an important cause of glomerular injury; however, the role of intercellular adhesion molecule (ICAM)-1 in the pathogenesis of glomerulosclerosis is not known. Methods To elucidate the effects of ICAM-1 depletion on hyperfiltration-induced glomerular disorder, we used subtotally nephrectomized ICAM-1?/? and ICAM-1-/- mice. We evaluated macrophage infiltration, mesangial matrix expansion, transforming growth factor (TGF)-b and type IV collagen accumulation in glomeruli. Results Macrophage infiltration into the glomeruli and mesangial matrix expansion coincident with increased expression of both ICAM-1 and TGF-b, and accumulation of type IV collagen were ameliorated in subtotally nephrectomized ICAM-1-/- mice compared to ICAM-1?/? mice. ICAM-1 depletion significantly reduced hyperfiltration- induced glomerular injury after renal ablation. Conclusions Our present findings suggest that glomerular hyperfiltration is the leading cause of glomerulosclerosis, and it is mediated, at least in part, by ICAM-1 expression and macrophage infiltration.
Clin Exp Nephrol (2011) 15:212–219 Received: 4 February 2010 / Accepted: 21 November 2010 / Published online: 23 December 2010 Japanese Society of Nephrology 2010
