Investigation of Molecular Mechanism of Chronic Pain in the Anterior Cingulate Cortex Using Genetically Engineered Mice
- نوع فایل : کتاب
- زبان : انگلیسی
- مؤلف : Susan S. Kim1, Giannina Descalzi1 and Min Zhuo*,1,2
- چاپ و سال / کشور: 2010
Description
Recent advances into the understanding of molecular mechanism of chronic pain have been largely developed through the use of genetic manipulations. This is in part due to the scarcity of selective pharmacological tools, which can be readily solved by creating knockout or transgenic mice. By identifying new genes that are of import, our efforts can then be aimed at studying relevant signaling pathways, and combination of pharmacological manipulations with genetic models can be used to further examine the specific mechanisms involved in chronic pain. In this review, we will examine the genetic models that are currently in use to study chronic pain in the anterior cingulate cortex: knockout mice; transgenic mice; and the strength of combining pharmacology with these genetic models.
Current Genomics, 2010, 11, 70-76 Received on: May 30, 2009 - Revised on: September 01, 2009 - Accepted on: September 09, 2009
