فن آوری تحویل برای بلجس: پپتیدها، پروتئین ها، اسیدهای نوکلئیک و واکسن Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals  Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.Content: Chapter 1 Challenges in Delivery of Biopharmaceuticals; the Need for Advanced Delivery Systems (pages 1–8): Hanne Morck Nielsen and Lene JorgensenChapter 2 Novel Formulation Approaches for Peptide and Protein Injectables (pages 9–28): Mingshi Yang and Sven FrokjaerChapter 3 Novel Non?Injectable Formulation Approaches of Peptides and Proteins (pages 29–67): Shirui Mao, Dongmei Cun and Yoshiaki KawashimaChapter 4 Chemical Vectors for Delivery of Nucleic Acid?Based Drugs (pages 69–92): Elizabeth A. Vasievich and Leaf HuangChapter 5 Viral Technology for Delivery of Nucleic Acids (pages 93–112): Shervin Bahrami and Finn Skou PedersenChapter 6 The Innate Immune Responses, Adjuvants and Delivery Systems (pages 113–127): S. Moein MoghimiChapter 7 Lipid Nanoparticle?Based Systems for Delivery of Biomacromolecule Therapeutics (pages 129–148): Susana Martins, Domingos C. Ferreira and Eliana B. SoutoChapter 8 Dendrimers in Delivery of Biopharmaceuticals (pages 149–168): Chandan Thomas and Fakhrul AhsanChapter 9 Modification of Peptides and Proteins (pages 169–191): Susanne Hostrup, Kasper Huus and Henrik ParshadChapter 10 Nanocarriers for the Delivery of Peptides and Proteins (pages 193–205): Kenneth LundstromChapter 11 Polymer?Based Delivery Systems for Oral Delivery of Peptides and Proteins (pages 207–226): Bruno Sarmento, Domingos Ferreira and Teofilo VasconcelosChapter 12 Advanced Pulmonary Delivery of Peptides or Proteins Using Polymeric Particles (pages 227–244): Yu Seok Youn, Kang Choon Lee, You Han Bae, Kun Na and Eun Seong LeeChapter 13 Polymer Microparticles for Nucleic Acid Delivery (pages 245–267): Tim Pearce, Jared Hierman and Chun WangChapter 14 Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics (pages 269–289): Qing Ge, David Evans, John J. Xu, Harry H. Yang and Patrick Y. LuChapter 15 Lipid?Based Formulations for siRNA Delivery (pages 291–304): Camilla Foged, Pieter Vader and Raymond M. SchiffelersChapter 16 Cellular Bioavailability of Peptide Nucleic Acids (PNAs) Conjugated to Cell Penetrating Peptides (pages 305–338): Takehiko Shiraishi and Peter E. NielsenChapter 17 DEAE?dextran?MMA Graft Copolymer for Non?Viral Delivery of DNA (pages 339–355): Yasuhiko Onishi, Yuki Eshita and Masaaki MizunoChapter 18 Liposomes in Adjuvant Systems for Parenteral Delivery of Vaccines (pages 357–376): Dennis Christensen, Karen Korsholm, Grith Kroyer Wood, Afzal Mohammed, Vincent Bramwell, Peter Andersen, Else Marie Agger and Yvonne PerrieChapter 19 Influenza Virosomes as Delivery Systems for Antigens (pages 377–393): Mario Amacker, Stefan Moese, Andreas R. Kammer, Ari Helenius and Rinaldo ZurbriggenChapter 20 GRAZAX®: An Oromucosal Vaccine for Treating Grass Pollen Allergy with Immunotherapy (pages 395–404): Annette Rommelmayer Lundegaard, Lise Lund and Jorgen Nedergaard LarsenChapter 21 Delivery Technologies for Biopharmaceuticals: A Critical Assessment (pages 405–412): Marco van de Weert