LH از آپوپتوز ناشی از سیس پلاتین در اووسیت ها جلوگیری کرده و باروری موش های ماده را حفظ می کند LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse
- نوع فایل : کتاب
- زبان : انگلیسی
- ناشر : NCBI
- چاپ و سال / کشور: 2017
توضیحات
رشته های مرتبط زیست شناسی، پزشکی
گرایش های مرتبط بیولوژی تولید مثل، علوم سلولی مولکولی، ژنتیک
مجله رسمی انجمن تشخیص مرگ سلول – Official journal of the Cell Death Differentiation Association
دانشگاه Department of Biomedicine and Prevention
نشریه نشریهNCBI
گرایش های مرتبط بیولوژی تولید مثل، علوم سلولی مولکولی، ژنتیک
مجله رسمی انجمن تشخیص مرگ سلول – Official journal of the Cell Death Differentiation Association
دانشگاه Department of Biomedicine and Prevention
نشریه نشریهNCBI
Description
In mammals, the growing follicles develop from a pool of primordial follicles constituted early in life. Despite a current lively debate,1 such follicles, termed the ovarian reserve, represent probably the only pool available for ovulation in the mammalian females during their entire reproductive life. Premature ovarian failure and infertility are routine side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes, mainly to the DNA-damaging effects of irradiation (IR) and chemotherapic drugs. At present, methods to preserve future fertility in cancer patients are invasive and in some cases still at experimental level.4 The development of chemotherapic agents that do not harm the ovarian reserve, or of substances capable of protecting oocytes from the deleterious effects of such drugs (‘fertoprotective agents’) would represent a major improvement to preserve fertility in women.
