تاثیر ایندومتروز بر نتیجه تکنولوژی کمک باروری The impact of endometriosis on the outcome of Assisted Reproductive Technology
- نوع فایل : کتاب
- زبان : انگلیسی
- ناشر : NCBI
- چاپ و سال / کشور: 2017
توضیحات
رشته های مرتبط زیست شناسی، پزشکی
گرایش های مرتبط بیولوژی تولید مثل، علوم سلولی مولکولی، ژنتیک
مجله زیست شناسی تولید مثل و غدد درون ریز – reproductive biology and endocrinology
نشریه نشریه NCBI
کلمات کلیدی ایندومتروز، ناباروری، تکنولوژی کمک باروری
گرایش های مرتبط بیولوژی تولید مثل، علوم سلولی مولکولی، ژنتیک
مجله زیست شناسی تولید مثل و غدد درون ریز – reproductive biology and endocrinology
نشریه نشریه NCBI
کلمات کلیدی ایندومتروز، ناباروری، تکنولوژی کمک باروری
Description
Background Endometriosis affects between 0.5 and 10% of women in reproductive age [1–3] and approximately 25–40% of women diagnosed with infertility [1]. Endometriosis is defined as the presence of endometrial tissue outside the uterine cavity [4]. This ectopic tissue induces a chronic inflammatory reaction that may lead to extensive fibrosis and adhesion formation. Clinically, endometriosis is classified as peritoneal, ovarian, and deep-infiltrating, although they often coexist [5]. Depending on the location of the endometriotic implant and the severity of the disease, several mechanisms have been postulated to explain the reduced fecundity observed in women affected by this condition. To date, the evidence suggests that endometriosis has deleterious effects on ovarian function [6, 7], tubal function [8], and may also affect endometrial receptivity [9]. Abnormal folliculogenesis and oocyte maturation [6, 7], increased radical oxidative stress [10, 11], as well as imbalances in the levels of cytokines, interleukins and various growth factors have been described as potential contributors to impaired fertility [11, 12]. There is a serious controversy as to whether endometriosis per se, can affect the reproductive outcomes of women undergoing assisted reproductive technologies (ART). Several authors have found that endometriosis have a negative impact [13–15], while others have not found such association [16–20]. The aim of this study is to compare, in a large cohort of women undergoing ART, the reproductive outcome of women with endometriosis with that of women without endometriosis.
