A Toll-Like Receptor 2/6 Agonis ...
Background: The hygiene hypothesis negatively correlates the microbial burden of the environment with the prevalence of T helper type 2 (Th2)-relate ...
Common Variable Immunodeficienc ...
One of the great advances in clinical medicine was the recognition of the pleomorphism of the immune response and the multiple afferent and efferent ...
Genomic characterization of the ...
Background: Mitochondrial tumor suppressor gene 1 (MTUS1) has been recently identified as a candidate tumor suppressor gene which resides in a genomi ...
The Bioartificial Kidney in the ...
Acute kidney injury (AKI) continues to have an exceedingly high mortality rate, despite advances in dialysis technology. Current dialysis therapies r ...
Targeting Matrix Metalloprotein ...
The matrix metalloproteinases (MMPs) and their endogenous regulators, the tissue inhibitors of MMPs (TIMPs) are responsible for the physiological rem ...
Role of ARBs in the Blood Hyper ...
Hypertension has a worldwide high incidence in the general population and undoubtedly it is the most important risk factor for cardiovascular morbidi ...
PDGF-D Signaling: A Novel Targe ...
Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation ...
Pathophysiology of Sepsis in th ...
The aging world population will increase the incidence and mortality of severe sepsis. The aim of the present article is to review the pathophysiolog ...
Pathogenesis of Acute Kidney In ...
Septic acute kidney injury (AKI) occurs between 15% and 20% of all intensive care unit admissions and its mortality ranges from 20% to 60%. The incid ...
NPY Signalling Pathway in Bone ...
Neuropeptide (NPY) is a neurotransmitter widely distributed in central and peripheral nervous system that has been implicated in several physiologica ...
Novel Therapeutic Targets for P ...
Sepsis associated Acute Kidney Injury (SA-AKI) is the leading cause of AKI in the hospital setting and its incidence is increasing. Although the exac ...
Splenic tuberculosis: a case re ...
Splenic tuberculosis is an unusual clinical phenomenon, especially in immunocompetent hosts. It often demonstrates diagnostic complexity, which makes ...
Novel Imaging Techniques in Acu ...
Imaging of the kidneys can provide valuable information in the work up and management of acute kidney injury. Several different imaging modalities ar ...
Monoclonal Antibodies in the Tr ...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B cell hyperactivity and defective T-cell function, with production of h ...
Molecular Targets in Malignant ...
Malignant mesothelioma is an aggressive tumour of the serosal surfaces with poor prognosis and increasing incidence due to widespread previous asbest ...
Molecular Recognition Models: A ...
Molecular recognition process describes the interaction involving two molecules. In the case of biomolecules, these pairs of molecules could be prote ...
Evaluation of the Level of HBV ...
Background and Aims: Hepatitis B infection is a serious public health problem worldwide. It has been shown that the levels of antibody to hepatitis B ...
Mechanisms of Action and Chemic ...
After a long initial stage obscured by empirism and misconceptions, oxygen-ozonetherapy has now become a scientific discipline where the reactions be ...
Interactions Between Advanced G ...
Diabetes, is a metabolic disorder characterised by chronic hyperglycaemia, hypertension, dyslipidaemia, microalbuminuria and inflammation. Moreover, ...
Inflammatory Systemic Biomarker ...
Clinicians have used additional tools to aid clinical assessment and to enhance their ability to identify the “vulnerable” patient at risk for cardio ...
Immune Mechanisms and Novel Pha ...
Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI) and both innate and adaptive immunity contribute to the pathogenesis. ...
HIV: A Raft-Targeting Approach ...
It has been widely accepted that HIV-1 enters into and buds out from microdomains known as lipid rafts/caveolae of plasma membranes of infected cells ...
Hepatitis B and Liver Transplan ...
Liver transplantation was approved for the treatment of decompensated cirrhosis in the United States in 1983. Hepatitis B and hepatitis C viruses are ...
Epidemiology of Septic Acute Ki ...
The incidence of sepsis and acute kidney injury (AKI) is increasing in critically ill patients and both portend a higher risk of morbidity and death. ...
Emerging Drug Candidates of Dip ...
Dipeptidyl peptidase IV (DPP IV) is a key regulator of insulin-stimulating hormones, glucagon-like peptide (GLP-1) and glucose-dependent insulinotrop ...