Computational Approaches for Predicting Causal Missense ...
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Computational Approaches for Pr ...
A central focus of cancer genetics is the study of mutations that are causally implicated in tumorigenesis. Although missense variants are commonly i ...
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The Absence of Ser389 Phosphory ...
Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. ...
1.99 MB
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Resistance of mitochondrial p53 ...
Background: Mutation of a tumor suppressor allele leaves the second as backup. Not necessarily so with p53. This homo-tetrameric transcription factor ...
132.63 KB
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Dissecting microregulation of a ...
Background: The master regulator p53 tumor-suppressor protein through coordination of several downstream target genes and upstream transcription fact ...
2.92 MB
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p53 induces distinct epigenetic ...
Background: The tumor suppressor protein p53 is a transcription factor that is mutated in many cancers. Regulation of gene expression by binding of w ...
1.49 MB
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Gene transfer: the challenge of ...
Gene therapy is expected to have a major impact on human healthcare in the future. However, precise regulation of therapeutic gene expression in viv ...
376.33 KB
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Nutritional Deficiencies in Mor ...
It is a common belief that clinical vitamin or mineral deficiencies are rare in Western countries because of the low-cost and unlimited diversity of ...
137.69 KB
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Fighting spinal cord complicati ...
Paraplegia or paraparesis after otherwise successful thoracic or thoracoabdominal aortic reconstruction is a devastating complication for both patie ...
216.94 KB
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An overview of current biomater ...
Today an increasing number of patients seek aesthetic improvement through minimally invasive procedures, and interest in soft tissue augmentation an ...
153.76 KB
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Acute urinary retention in preg ...
Female acute urinary retention in pregnancy is a relatively uncommon condition. Its relatively low incidence and little published evidence base lead ...
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Uterine lipoleiomyoma: transvag ...
Uterine lipoleiomyoma is a rare benign tumor. It can be easily misdiagnosed as an ovarian origin teratoma on radiological imaging studies. We report ...
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D-dimer negative deep vein thro ...
Venous thrombo-embolism (VTE) is a major cause of morbidity and mortality during pregnancy. Most of the evidence being used in the management of thi ...
93.18 KB
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Leiomyosarcoma of the broad lig ...
Leiomyosarcoma of the broad ligament is a rare tumor, with only 16 cases. In this paperwe examine the case of a 52-year-old women consulted for pelv ...
168.62 KB
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Wolff–Parkinson syndrome in pre ...
Though uncommon, Wolff–Parkinson–White syndrome (WPW) can cause life threatening cardiac rhythm disorders in pregnancy. We examine a case report of ...
135.76 KB
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Pregnancy in chronic renal fail ...
Although unusual, pregnancy in chronic dialysis patients does occur. In fact, the percent of successful pregnancies in women on chronic dialysis may ...
116.13 KB
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Evaluation of office hysterosco ...
To assess whether outpatient hysteroscopy without anesthesia confers any advantages over the traditional technique, we conducted a retrospective stu ...
89.91 KB
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Management of radial sclerosing ...
Background Radial sclerosing lesions (RSLs) of the breast are benign lesions that can mimic carcinoma on mammography and are frequently associated w ...
453.65 KB
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Diagnosis of rejection after li ...
Background: In vivo hepatic phosphorus-31 magnetic resonance spectroscopy (31P-MRS) provides non-invasive information about phospholipid metabolism. ...
378.27 KB
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ACTH-independent macronodular a ...
disease. Most cases being ACTH-dependent. ACTHindependent Cushing’s syndrome (AICS) is an even rarer condition (15%–20%). In more than 95% cases, th ...
403.38 KB
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Chemoembolization of hepatic ma ...
Treatment of primary and secondary hepatic malignancies with transarterial chemoembolization (TACE) represents an essential component of interventio ...
489.59 KB
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MRCP of congenital pancreaticob ...
malformations are sometimes associated with acute or chronic pancreatitis and biliary carcinoma. Currently, MRCP is one of the first choices for in ...
326.19 KB
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In vitro derivation of function ...
The capacity for self-renewal and differentiation of human embryonic stem (ES) cells makes them a potential source for generation of pancreatic beta ...
1.34 MB
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Induction of Pluripotent Stem C ...
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem ...
2.03 MB
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The Cost of Biopharmaceutical R ...
The costs of developing the types of new drugs that have been pursued by traditional pharmaceutical firms have been estimated in a number of studies. ...
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Gene Expression Profiles of Chl ...
The obligate intracellular, gram-negative bacterium Chlamydophila pneumoniae (Cpn) has impact as a human pathogen. Little is known about changes in t ...
1.40 MB
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