The HLA Region and Autoimmune Disease: Associations and ...
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The HLA Region and Autoimmune D ...
The HLA region encodes several molecules that play key roles in the immune system. Strong association between the HLA region and autoimmune disease ( ...
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Osmoadaptation of Mammalian Cel ...
In mammals, the cells of the renal medulla are physiologically exposed to interstitial osmolalities several-fold higher that found in any other tissu ...
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Meiosis-Driven Genome Variation ...
Meiosis includes two successive divisions of the nucleus with one round of DNA replication and leads to the formation of gametes with half of the chr ...
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Nutrigenomics, ..-Cell Function ...
“Nutrigenomics” refers to the ability of nutrients to alter gene expression. Insulin secreting ک-cells exhibit genomic and molecular changes that enh ...
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Real-Time PCR: Revolutionizing ...
Invention of polymerase chain reaction (PCR) technology by Kary Mullis in 1984 gave birth to real-time PCR. Real-time..PCR — detection and expression ...
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Consensus Higher Order Repeats ...
Key string algorithm (KSA) could be viewed as robust computational generalization of restriction enzyme method. KSA enables robust and effective iden ...
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A General Quantitative Genetic ...
Uncertainty about linkage phases of multiple single nucleotide polymorphisms (SNPs) in heterozygous diploids challenges the identification of specifi ...
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Patterns of Insertion and Delet ...
Nucleotide insertions and deletions (indels) are responsible for gaps in the sequence alignments. Indel is one of the major sources of evolutionary c ...
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Challenges and Solutions in Pro ...
The accelerated growth of proteomics data presents both opportunities and challenges. Large-scale proteomic profiling of biological samples such as c ...
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Pas de deux: Natural Killer Rec ...
Major histocompatibility complex (MHC) class I and NK cell receptor gene regions are a paradigm of genomic plasticity as they reveal a considerable d ...
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Zebrafish as a Model System to ...
Zebrafish (Danio rerio) is a bona fide vertebrate model system for understanding human diseases. It allows the transparent visualization of the effec ...
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Megsin Gene: Its Genomic Analys ...
It is critical to uncover genes specifically expressed in individual cell types for further understanding of cell biology and pathology. In order to ...
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Genetic and Environmental Facto ...
Complex neurodevelopmental disorders, such as schizophrenia, autism, attention deficit (hyperactivity) disorder, (manic) depressive illness and addic ...
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Myostatin in the Pathophysiolog ...
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved acr ...
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H2A.Z-Mediated Genome-Wide Chro ...
The characterization of the involvement of different histone post-translational modifications (PTMs) and histone variants in chromatin structure has ...
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Recent Computational Approaches ...
This paper reviews recent computational approaches to the understanding of gene regulation in eukaryotes. Cis-regulation of gene expression by the bi ...
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Gene Expression Profiling and i ...
The availability of sequenced genomes of human and many experimental animals necessitated the development of new technologies and powerful computatio ...
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Cautionary Tail: The Presence o ...
As part of structural investigations of components of the molecular motor, dynein, we prepared the light chain, Robl1_mouse, with and without an N-te ...
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Parallel Gene Expression Profil ...
DNA microarray technology has been a valuable tool to provide a global view of the changes in gene expression that characterize different types of B ...
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Longevity Genomics Across Speci ...
Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determin ...
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Current Therapeutic Options for ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the developed world. The increasing life expectancy in the last years has le ...
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Gene Expression Studies in Mult ...
Abstract: Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 ...
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The Human Pseudoautosomal Regio ...
The pseudoautosomal regions (PAR1 and PAR2) of the human X and Y chromosomes pair and recombine during meiosis. Thus genes in this region are not inh ...
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Role of Insulin and Growth Horm ...
Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling pathways involved in the control of lifespans in lower org ...
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Ribosomal Proteins and Colorect ...
The ribosome is essential for protein synthesis. The composition and structure of ribosomes from several organisms have been determined, and it is we ...
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