The MDM2 Ubiquitination Signal in the DNA-Binding Domai ...
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The MDM2 Ubiquitination Signal ...
Genetic and biochemical studies have shown that Ser20 phosphorylation in the transactivation domain of p53 mediates p300-catalyzed DNA-dependent p53 ...
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Multiple Functions of Rad9 for ...
DNA-damage checkpoints sense and respond to genomic damage. Human Rad9 (hRad9), an evolutionarily conserved gene with multiple functions for preservi ...
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Gβγ-Copurified Lipid Kinase Imp ...
G-protein .... dimers are prime regulators transmitting extracellular signals to wide-ranging cellular effectors including phosphoinositide 3-kinase ...
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The Absence of Ser389 Phosphory ...
Phosphorylation is important in p53-mediated DNA damage responses. After UV irradiation, p53 is phosphorylated specifically at murine residue Ser389. ...
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Ribosomal Proteins and Colorect ...
The ribosome is essential for protein synthesis. The composition and structure of ribosomes from several organisms have been determined, and it is we ...
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The Role of the COG Database in ...
A major breakthrough in classifying proteins from different microbial genomes in terms of sequence similarity was the development of the COG concept ...
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Role of Insulin and Growth Horm ...
Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling pathways involved in the control of lifespans in lower org ...
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Bcl2’s Flexible Loop Domain Reg ...
p53 not only functions as a transcription factor but also has a direct, apoptogenic role at the mitochondria. We have discovered that DNA damage-indu ...
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The Human Pseudoautosomal Regio ...
The pseudoautosomal regions (PAR1 and PAR2) of the human X and Y chromosomes pair and recombine during meiosis. Thus genes in this region are not inh ...
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Gene Expression Studies in Mult ...
Abstract: Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 ...
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Molecular Signature of HPV-Indu ...
The infection by mucosal human papillomavirus (HPV) is causally associated with tumor development in cervix and oropharynx. The mechanisms responsibl ...
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Modifiers of Hearing Impairment ...
Lack of penetrance and variability of expression are common findings in nonsyndromic hearing loss with autosomal dominant mode of inheritance, but ar ...
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Current Therapeutic Options for ...
Alzheimer’s disease (AD) is the most common neurodegenerative disease in the developed world. The increasing life expectancy in the last years has le ...
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Recent Progress in Functional G ...
With the completion and near completion of many malaria parasite genome-sequencing projects, efforts are now being directed to a better understanding ...
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Genetics Talks to Epigenetics? ...
Transcription is regulated by two major mechanisms. On the one hand, changes in DNA sequence are responsible for genetic gene regulation. On the othe ...
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Computational Approaches for Pr ...
A central focus of cancer genetics is the study of mutations that are causally implicated in tumorigenesis. Although missense variants are commonly i ...
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Feud or Friend? The Role of the ...
MicroRNAs (miRNAs) are short, noncoding, and single-stranded RNA molecules that negatively regulate gene expression. They are evolutionarily conserve ...
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Longevity Genomics Across Speci ...
Unbiased genome-wide studies of longevity in S. cerevisiae and C. elegans have led to the identification of more than one hundred genes that determin ...
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Genomics of Fungal Disease Resi ...
Tomato (Solanum lycopersicum) is an important vegetable crop worldwide. Often times, its production is hindered by fungal diseases. Important fungal ...
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Midkine is a NF-κB-inducible ge ...
Background: Midkine is a heparin-binding growth factor that is over-expressed in various human cancers and plays important roles in cell transformati ...
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Using Free and Open-Source Bioc ...
Whole-genome array Comparative Genomics Hybridization (aCGH) can be used to scan chromosomes for deletions and amplifications. Because of the increas ...
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Do mtDNA Mutations Participate ...
The pathogenesis of sporadic Parkinson’s disease (PD) remains enigmatic. Mitochondrial complex-I defects are known to occur in the substantia nigra ( ...
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Parallel Gene Expression Profil ...
DNA microarray technology has been a valuable tool to provide a global view of the changes in gene expression that characterize different types of B ...
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Gene Clusters, Molecular Evolut ...
Traditionally eukaryotic genes are considered independently expressed under the control of their promoters and cis-regulatory domains. However, recen ...
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The Decade of Vaccines: An Oppo ...
Despite remarkable improvement in global immunisation coverage during the past 30 years, progress has not been uniform. The reasons underlying sub-op ...
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